Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Apr 2024
Clinical biomarker-based biological ageing and future risk of neurological disorders in the UK Biobank.
Many common neurological disorders are associated with advancing chronological age, but their association with biological age (BA) remains poorly understood. ⋯ Advanced BA calculated from routine clinical biomarker results increases the risk of subsequent neurological diagnoses including all-cause dementia and ischaemic stroke.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2024
Predictive value of retinal atrophy for cognitive decline across disease duration in multiple sclerosis.
We investigated the association between changes in retinal thickness and cognition in people with MS (PwMS), exploring the predictive value of optical coherence tomography (OCT) markers of neuroaxonal damage for global cognitive decline at different periods of disease. ⋯ The progressive retinal thinning is related to cognitive decline, indicating that cognitive dysfunction is a late manifestation of accumulated neuroaxonal damage. Quantifying the pRFNL aids in identifying individuals at risk of cognitive dysfunction.
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J. Neurol. Neurosurg. Psychiatr. · Mar 2024
Observational StudyDo lower limb motor-evoked potentials predict walking outcomes post-stroke?
This observational study examined whether lower limb (LL) motor-evoked potentials (MEPs) 1 week post-stroke predict recovery of independent walking, use of ankle-foot orthosis (AFO) or walking aid, at 3 and 6 months post-stroke. ⋯ The presence of LL MEPs 1-week post-stroke predicts independent walking at 3 and 6 months post-stroke. However, the absence of MEPs does not preclude independent walking. Clinical factors, particularly age, balance and stroke severity, more strongly predict independent walking than MEP status. LL MEP status adds little value as a biomarker for walking outcomes.