Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Nov 2014
Mortality and morbidity 15 years after hospital admission with mild head injury: a prospective case-controlled population study.
To investigate mortality rate in a population of adults admitted to hospital with mild head injury (MHI) 15 years later. ⋯ Adults hospitalised with MHI had greater risk of death in the following 15 years than matched controls. The extent to which lifestyle and potential chronic changes in neuropathology explain these findings is unclear. Lifestyle factors do contribute to risk of death after MHI and this finding has implications for lifestyle management interventions.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2014
The impact and prognosis for dystonia in childhood including dystonic cerebral palsy: a clinical and demographic tertiary cohort study.
The impact of dystonia in childhood is poorly understood. We report our experience of referrals between 2005 and 2012. ⋯ In this selective cohort, childhood dystonia is severe, presenting early before worsening without remission. Secondary dystonias spend a higher proportion of life living with dystonia and lower functional capacity. Despite referral bias, services offering neurosurgical interventions and health service planning agencies should understand the context and predicament of life with childhood dystonia.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2014
Apolipoprotein E ε2 genotype delays onset of dementia with Lewy bodies in a Norwegian cohort.
Results conflict concerning the relevance of APOE alleles on the development of dementia with Lewy bodies (DLB), though they are well established in connection with Alzheimer's disease (AD). The role of APOE alleles in a Norwegian cohort of patients with DLB was therefore examined compared with patients with AD and healthy control individuals. ⋯ The results indicate that APOE ε2, a protective factor in AD, has a clear beneficial effect on the development of DLB also.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2014
Application of whole exome sequencing in undiagnosed inherited polyneuropathies.
Inherited polyneuropathies often go undiagnosed. We investigated whole exome sequencing (WES) in utility to identify the genetic causes of diverse forms of inherited polyneuropathies without genetic diagnosis. ⋯ Diverse inherited neuropathy patients without genetic discovery by candidate gene testing have a favourable probability of receiving a genetic diagnosis by WES. Frequently, atypical phenotypes account for earlier failed candidate approaches, and WES is demonstrated to expand the clinical spectrum of known pathogenic mutations.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2014
Cerebral infarction and tuberculoma in central nervous system tuberculosis: frequency and prognostic implications.
Tuberculoma and cerebral infarctions are serious complications of central nervous system (CNS) tuberculosis. However, there are no studies comparing prognostic value of tuberculoma and infarcts alone and in patients diagnosed with CNS tuberculosis. ⋯ Tuberculomas were present in 50% of patients, while infarcts were present in 25%. Old age, TBM grading, presence of infarction and hydrocephalus were all predictors of poor outcome.