Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Jan 2014
PREDICT-PD: identifying risk of Parkinson's disease in the community: methods and baseline results.
To present methods and baseline results for an online screening tool to identify increased risk for Parkinson's disease (PD) in the UK population. ⋯ PREDICT-PD is the first study to systematically combine risk factors for PD in the general population. Validity to predict risk of PD will be tested through longitudinal follow-up of incident PD diagnosis.
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J. Neurol. Neurosurg. Psychiatr. · Jan 2014
Extrastriatal dopaminergic changes in Parkinson's disease patients with impulse control disorders.
To investigate the extrastriatal dopaminergic neural changes in relation to the medication-related impulse control disorders (ICD) in Parkinson's disease (PD). ⋯ A great gap in extrastriatal versus striatal dopaminergic fibre degenerations is an intrinsic condition predisposing to ICD in PD. Distinct pattern of extrastriatal changes between the ICD and non-ICD patients could provide a further insight into a mechanism of ICD in PD.
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J. Neurol. Neurosurg. Psychiatr. · Jan 2014
Exploratory analysis of neuropsychological and neuroanatomical correlates of progressive mild cognitive impairment in Parkinson's disease.
Parkinson's disease with mild cognitive impairment (PD-MCI) is a heterogeneous entity in terms of cognitive profiles and conversion to dementia. However, the risk factors for ongoing cognitive decline in patients with PD-MCI are not clearly defined. ⋯ Our data show that atrophy in the frontostriatal areas and cholinergic structures, as well as frontal lobe associated cognitive performance, may act as predictors of dementia in PD-MCI patients, suggesting distinctive patterns of cognitive profiles and a neuroanatomical basis for progressive PD-MCI.
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J. Neurol. Neurosurg. Psychiatr. · Jan 2014
Age, gender and tumour size predict work capacity after surgical treatment of vestibular schwannomas.
The aim of the present study was to identify predictive factors for outcome after surgery of vestibular schwannomas. ⋯ The SF36 questionnaire did not correlate to outcome measures as WC and IL in patients undergoing surgery for vestibular schwannomas. Women and patients above 50 years with larger tumours have a high risk for reduced WC after surgical treatment. These results question the validity of quality of life scores in assessment of outcome after surgery of benign skullbase lesions.