Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Jun 2013
Editorial CommentCerebral microbleeds and cognitive function.
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J. Neurol. Neurosurg. Psychiatr. · Jun 2013
Biography Historical ArticleEugen Bleuler (1857-1939), an early pioneer of evidence based medicine.
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J. Neurol. Neurosurg. Psychiatr. · May 2013
Cortical atrophy in presymptomatic Alzheimer's disease presenilin 1 mutation carriers.
Sporadic late-onset Alzheimer's disease (AD) dementia has been associated with a 'signature' of cortical atrophy in paralimbic and heteromodal association regions measured with MRI. ⋯ Results demonstrate that cognitively normal individuals genetically determined to develop AD have a thinner cerebral cortex than non-carriers in regions known to be affected by typical late-onset sporadic AD. These findings provide further support for the hypothesis that cortical atrophy is present in preclinical AD more than 5 years prior to symptom onset. Further research is needed to determine whether this method could be used to characterise the age-dependent trajectory of cortical atrophy in presymptomatic stages of AD.
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Multiple sclerosis (MS) is an inflammatory and neurodegenerative disorder of the CNS that is frequently associated with neuropsychiatric symptoms and decreased quality of life. Social support, which has been found to buffer the psychosocial burden of MS, critically depends on intact social cognition. Here we assess social cognition in patients with MS using a naturalistic video based test and explore if potential deficits in theory of mind (ToM) occur independently of known MS associated neuropsychiatric symptoms, such as depression and cognitive impairment. ⋯ These results suggest impaired social cognition in MS. Importantly, ToM impairments in this group may not simply be a consequence of the well known neuropsychological deficits. Difficulties with correctly identifying emotions, thoughts and intentions in social situations may result in interpersonal problems and could contribute to the psychosocial burden of MS.