Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Apr 2013
Review Meta AnalysisThe month of birth effect in multiple sclerosis: systematic review, meta-analysis and effect of latitude.
Month of birth has previously been described as a risk factor for multiple sclerosis (MS). This has been hypothesised to be related to maternal vitamin D levels during pregnancy, although conclusive evidence to support this is lacking. To date, no large studies of latitudinal variation in the month of birth effect have been performed to advance this hypothesis. ⋯ Month of birth has a significant effect on subsequent MS risk. This is likely to be due to ultraviolet light exposure and maternal vitamin D levels, as demonstrated by the relationship between risk and latitude.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2013
Case ReportsNeurological manifestations of phaeochromocytomas and secretory paragangliomas: a reappraisal.
To determine the frequency and range of neurological manifestations of phaeochromocytomas and secretory paragangliomas. ⋯ Neurological manifestations of phaeochromocytomas and secretory paragangliomas were common, and these tumours can present with various neurological manifestations. The paroxysmal symptoms can be incorrectly attributed to other headache syndromes, panic attacks or cerebral vasculitis. RCVS may play a role in the pathogenesis of the neurological symptoms associated with acute crises and paroxysmal attacks.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2013
ReviewParkinson's disease subtypes: lost in translation?
Like many neurodegenerative disorders, Parkinson's disease (PD) is clinically highly heterogeneous. A number of studies have proposed and defined subtypes of PD based on clinical features that tend to cluster together. ⋯ We then discuss what the subtypes could tell us about the disease and how they have been incorporated into studies of aetiology, progression and treatment. Finally, with the knowledge that they have been incorporated very little into PD clinical research, we make recommendations for how subtypes should be used and make some practical recommendations to address this lack of knowledge translation.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2013
Case Reports Multicenter StudyTremor in primary adult-onset dystonia: prevalence and associated clinical features.
To investigate the frequency and the main clinical features of tremor in primary adult-onset dystonia (PAOD). ⋯ Tremor is a relatively common feature occurring in about 17% of patients with primary late-onset dystonia. The association between tremor and dystonia spread suggests that this form of tremor may be a dystonic manifestation. Similarities in phenotypic features of DT and TAWD predominated over differences, suggesting that the two forms of tremor may be manifestations of the same disease. Differences in gender and body distribution of tremor between patients with dystonia and tremor and those of patients with essential tremor also suggest that tremor in dystonia and essential tremor are different entities.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2013
Progressive changes in a recognition memory network in Parkinson's disease.
In a previous functional MRI (fMRI) study, we found that patients with Parkinson's disease (PD) presented with dysfunctions in the recruitment of recognition memory networks. We aimed to investigate the changes in these networks over time. ⋯ Model free fMRI and cross correlation connectivity analyses were able to detect progressive changes in functional networks involved in recognition memory in PD patients at early disease stages and without overt clinical deterioration. Functional connectivity analyses could be useful to monitor changes in brain networks underlying neuropsychological deficits in PD.