Journal of neurology, neurosurgery, and psychiatry
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To assess the diagnostic value of the bereitschaftspotential (BP) in jerky movement disorders. ⋯ We demonstrate that the BP can aid in the differentiation of jerky movements. Patients with psychogenic jerks significantly more often have a BP prior to their jerks and with a significantly earlier onset compared with GTS patients. A novel finding of our study is the absence of a BP prior to intentional movements for patients with psychogenic jerks. Validation in a prospective cohort is needed.
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J. Neurol. Neurosurg. Psychiatr. · Dec 2012
Episodic memory and the medial temporal lobe: not all it seems. Evidence from the temporal variants of frontotemporal dementia.
Disproportionate medial temporal lobe atrophy (MTA) is an early finding in Alzheimer's disease (AD). Episodic memory impairment in AD is associated with the degree of MTA. Episodic memory impairment and MTA are also found in semantic dementia (SD) and in right temporal lobe atrophy (RTLA), the temporal variants of frontotemporal dementia, but their relationship is unclear. ⋯ Since episodic memory impairment is more severe in AD than in SD and RTLA, despite a comparable degree of MTA, atrophy of the medial temporal lobe alone cannot account for episodic memory dysfunction.
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J. Neurol. Neurosurg. Psychiatr. · Dec 2012
7 T MRI reveals diffuse iron deposition in putamen and caudate nucleus in CADASIL.
Diffuse iron deposition in the brain is commonly found in older people. One of the possible mechanisms that contribute to this iron deposition is cerebral small vessel disease. The aim of this study is to quantify diffuse iron deposition in patients with the hereditary small vessel disease cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). ⋯ This study demonstrates increased diffuse iron accumulation in the putamen and caudate nucleus in patients with the small vessel disease CADASIL. This supports the hypothesis that small vessel disease contributes to the process of increased iron accumulation in the general population.
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J. Neurol. Neurosurg. Psychiatr. · Dec 2012
Low vitamin D and elevated immunoreactivity against Epstein-Barr virus before first clinical manifestation of multiple sclerosis.
Vitamin D deficiency and Epstein-Barr virus (EBV) infection may be associated with the development of multiple sclerosis (MS). We investigated serum 25-hydroxyvitamin D (25-OH-D) levels and anti-EBV immunoreactivity in 25 individuals before the first clinical manifestation of MS. ⋯ Low vitamin D and remote EBV infection may be associated with clinical MS breakthrough within 2-3 years.
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J. Neurol. Neurosurg. Psychiatr. · Dec 2012
Risk and outcomes for traumatic brain injury in patients with mental disorders.
To investigate the risk of traumatic brain injury (TBI) and post-injury mortality in patients with mental disorders. ⋯ Patients with mental disorders have an increased risk of TBI. Intensity of psychiatric medication is associated with increased post-injury mortality. Special attention to prevent TBI among this disabled population is mandatory.