Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Dec 2010
Sleep-wake disturbances 3 years after traumatic brain injury.
6 months after traumatic brain injury (TBI), almost three out of four patients suffer from sleep-wake disturbances (SWD) such as post-traumatic hypersomnia (increased sleep need of ≥2 h compared with before injury), excessive daytime sleepiness (EDS), fatigue and insomnia. The long-term course of post-traumatic SWD, however, is unknown. ⋯ This prospective study shows that 3 years after TBI, two out of three patients suffer from residual SWD, particularly fatigue and post-traumatic hypersomnia. In 45% of TBI patients, SWD appear directly related to the trauma itself.
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J. Neurol. Neurosurg. Psychiatr. · Dec 2010
Early central atrophy rate predicts 5 year clinical outcome in multiple sclerosis.
To examine the predictive value of central atrophy in early multiple sclerosis (MS) patients, for medium term clinical outcome. ⋯ The rate of ventricular enlargement seems to be even more strongly predictive of disease progression after medium term follow-up than whole brain atrophy rate, and also outperforms lesion measures. Central atrophy rate could therefore be an important prognostic marker, especially in the early stages of MS.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2010
Controlled Clinical TrialHome telemonitoring of non-invasive ventilation decreases healthcare utilisation in a prospective controlled trial of patients with amyotrophic lateral sclerosis.
Non-invasive ventilation (NIV) is an efficient method for treating respiratory failure in patients with amyotrophic lateral sclerosis (ALS). However, it requires a process of adaptation not always achieved due to poor compliance. The role of telemonitoring of NIV is not yet established. ⋯ This study shows that telemonitoring reduces health care utilisation with probable favourable implications on costs, survival and functional status.