Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · May 2023
Timing of physical activity across adulthood on later-life cognition: 30 years follow-up in the 1946 British birth cohort.
To assess how timing, frequency and maintenance of being physically active, spanning over 30 years in adulthood, is associated with later-life cognitive function. ⋯ Being physically active at any time in adulthood, and to any extent, is linked with higher later-life cognitive state, but lifelong maintenance of physical activity was most optimal. These relationships were partly explained by childhood cognition and education, but independent of cardiovascular and mental health and APOE-E4, suggestive of the importance of education on the lifelong impacts of physical activity.
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J. Neurol. Neurosurg. Psychiatr. · May 2023
Adult-onset epilepsy and risk of traumatic brain injury: a nationwide cohort study.
A knowledge gap exists regarding the risk of traumatic brain injury (TBI) in patients with epilepsy. ⋯ Patients with adult-onset epilepsy have a significantly increased risk of severe and fatal TBI. The results underline the importance of TBI prevention in epilepsy.
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J. Neurol. Neurosurg. Psychiatr. · May 2023
Spasticity treatment patterns among people with multiple sclerosis: a Swedish cohort study.
Spasticity is common among people with multiple sclerosis (MS), but there are few studies of spasticity treatment patterns. We aim to describe associations with spasticity treatment measured primarily by oral baclofen use. ⋯ Younger patients with MS are more likely to receive baclofen compared with older patients with MS. High rates of baclofen discontinuation highlight the need for more tolerable and efficacious spasticity treatments and monitoring of spasticity among people with MS.
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J. Neurol. Neurosurg. Psychiatr. · May 2023
Insufficient sleep during adolescence and risk of multiple sclerosis: results from a Swedish case-control study.
Shift work, which often results in sleep deprivation and circadian desynchrony, has been associated with increased risk of multiple sclerosis (MS). We aimed at studying the impact of sleep duration, circadian disruption and sleep quality on MS risk. ⋯ Insufficient sleep and low sleep quality during adolescence seem to increase the risk of subsequently developing MS. Sufficient restorative sleep at young age, needed for adequate immune functioning, may be a preventive factor against MS.