Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Dec 2006
Clinical TrialEffect of levodopa on cognitive function in Parkinson's disease with and without dementia and dementia with Lewy bodies.
Levodopa (L-dopa) is the gold standard treatment for Parkinson's disease, but a lack of clear efficacy combined with a perceived liability to neuropsychiatric side effects has limited L-dopa use in patients with parkinsonism and dementia. Therefore, the effect of L-dopa on the cognitive profile of dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) is unclear. ⋯ The use of L-dopa in patients with parkinsonism with dementia does not adversely affect cognitive function.
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J. Neurol. Neurosurg. Psychiatr. · Dec 2006
Acute physiological derangement is associated with early radiographic cerebral infarction after subarachnoid haemorrhage.
Cerebral infarction after aneurysmal subarachnoid haemorrhage (SAH) is presumed to be due to cerebral vasospasm, defined as arterial lumen narrowing from days 3 to 14. ⋯ Many cerebral infarctions after SAH are unlikely to be caused by vasospasm because they occur too soon after SAH or because angiography shows no vasospasm in a referable artery, or both. Physiological derangement and cerebral oedema may be worthwhile targets for intervention to decrease the occurrence and clinical impact of cerebral infarction after SAH.
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J. Neurol. Neurosurg. Psychiatr. · Dec 2006
Editorial CommentPrevention of delayed cerebral ischaemia after subarachnoid haemorrhage.
Physiological abnormalities are a worthwhile target
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J. Neurol. Neurosurg. Psychiatr. · Nov 2006
Functional status and use of healthcare facilities in long-term survivors of transient ischaemic attack or minor ischaemic stroke.
Stroke may have a major effect on survivors and on the healthcare system. ⋯ Recurrent stroke and the presence of comorbidity of locomotion are important determinants of long-term disability of survivors of a TIA or an MIS, which, in turn, is strongly associated with the long-term use of professional care. The need for measuring comorbidity with regard to functional status is recommended in research on stroke outcome.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2006
Meta AnalysisIs hypertension a more frequent risk factor for deep than for lobar supratentorial intracerebral haemorrhage?
To determine whether evidence from observational studies supports the widely held belief that hypertension is more commonly a risk factor for deep than for lobar supratentorial intracerebral haemorrhage. ⋯ An excess of hypertension was found in patients with deep versus lobar intracerebral haemorrhages without an identified secondary cause, but this may be due to residual, unquantified methodological biases.