Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · May 2006
Time dependent validity in the diagnosis of brain death using transcranial Doppler sonography.
To evaluate the validity of transcranial Doppler (TCD) in confirming brain death from various pathological conditions. ⋯ TCD can be a confirmatory tool for diagnosing brain death. The validity of TCD diagnosed brain death depends on the time lapse between brain death and the performance of TCD. TCD of both the basilar artery and the MCAs showed significant consistency in brain death diagnosis.
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J. Neurol. Neurosurg. Psychiatr. · May 2006
Editorial CommentCan severely disabled patients benefit from in-patient neurorehabilitation for acquired brain injury?
Neurorehabilitation may be most cost efficient in those with the most severe disability
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J. Neurol. Neurosurg. Psychiatr. · May 2006
Letter Case ReportsParkinsonism in type 1 Gaucher's disease.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2006
Variability of antiepileptic medication taking behaviour in sudden unexplained death in epilepsy: hair analysis at autopsy.
Variable compliance with antiepileptic drugs (AEDs) is a potentially preventable cause of sudden unexplained death in epilepsy (SUDEP). Hair AED concentrations provide a retrospective insight into AED intake variability. ⋯ Observed variability of hair AED concentrations, reflecting variable AED ingestion over time, is greater in patients dying from SUDEP than in either epilepsy outpatients or inpatients. SUDEP, at least in a proportion of cases, appears preventable.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2006
Clinical and neuropsychological follow up at 12 months in patients with complicated Parkinson's disease treated with subcutaneous apomorphine infusion or deep brain stimulation of the subthalamic nucleus.
The clinical condition of advanced Parkinson's disease (PD) patients is often complicated by motor fluctuations and dyskinesias which are difficult to control with available oral medications. ⋯ Both APO and STN-DBS resulted in significant clinical improvement in complicated PD. STN-DBS resulted in greater reduction in dopaminergic medications and provided 24 h motor benefit. However, STN-DBS, unlike APO, appears to be associated with significant worsening on NPI resulting from long term behavioral problems in some patients.