Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Mar 2006
Location characteristics of early perihaematomal oedema.
The natural history and triggers of perihaematomal oedema (PHO) remain poorly understood. Cerebral amyloid angiopathy (a common cause of lobar haemorrhage) has localised anticoagulant and thrombolytic properties, which may influence PHO. We hypothesised that early (within 24 hours) oedema to haematoma volume ratios are smaller in patients with lobar intracerebral haemorrhage (ICH) than in patients with deep ICH. ⋯ There are no major location specific differences in PHO volumes within 24 hours of ICH onset. Deep and lobar ICH may have common therapeutic targets to reduce early PHO.
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J. Neurol. Neurosurg. Psychiatr. · Mar 2006
Editorial Comment Comparative StudyNational variations in mortality and functional outcome: should we be worried?
International registries should be established to monitor process and outcome of care after stroke
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J. Neurol. Neurosurg. Psychiatr. · Mar 2006
Retraction Of PublicationPsychiatric side effects during methysergide treatment.
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J. Neurol. Neurosurg. Psychiatr. · Feb 2006
Neuropsychological characteristics of mild cognitive impairment subgroups.
To describe the neuropsychological characteristics of mild cognitive impairment (MCI) subgroups identified in the Cardiovascular Health Study (CHS) cognition study. ⋯ The most frequent form of MCI was the MCI-MCDT with memory deficits. However, the identification of memory impaired MCI groups did not reflect the true prevalence of MCI in a population, as 16% of all MCI cases and 21.5% of the MCI-MCDT cases did not have memory impairment. Study of idiopathic amnestic and non-amnestic forms of MCI is essential for an understanding of the aetiology of MCI.
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J. Neurol. Neurosurg. Psychiatr. · Feb 2006
Critical thresholds of intracranial pressure and cerebral perfusion pressure related to age in paediatric head injury.
The principal strategy for managing head injury is to reduce the frequency and severity of secondary brain insults from intracranial pressure (ICP) and cerebral perfusion pressure (CPP), and hence improve outcome. Precise critical threshold levels have not been determined in head injured children. ⋯ The PTI is the first substantive paediatric index of total ICP and CPP following head injury. The insult thresholds generated are identical to age related physiological values. Management guidelines for paediatric head injuries should take account of these CPP thresholds to titrate appropriate pressor therapy.