Journal of neurology, neurosurgery, and psychiatry
-
J. Neurol. Neurosurg. Psychiatr. · Jan 2004
Randomized Controlled Trial Multicenter Study Clinical TrialRopinirole in the treatment of restless legs syndrome: results from the TREAT RLS 1 study, a 12 week, randomised, placebo controlled study in 10 European countries.
To assess the efficacy, safety, and tolerability of ropinirole in the treatment of patients with restless legs syndrome. ⋯ Ropinirole improves restless legs syndrome compared with placebo, with benefits apparent by week 1. It is generally well tolerated.
-
J. Neurol. Neurosurg. Psychiatr. · Jan 2004
Clinical TrialPersistence of pain induced by startle and forehead cooling after sympathetic blockade in patients with complex regional pain syndrome.
Stimuli arousing sympathetic activity can increase ratings of clinical pain in patients with complex regional pain syndrome (CRPS). ⋯ These findings suggest that stimuli arousing sympathetic activity act by a central process to exacerbate pain in some patients, independent of the peripheral sympathetic nervous system. This may account for the lack of effect of peripheral sympathetic blockade on pain in some CRPS patients.