Journal of neurology, neurosurgery, and psychiatry
-
J. Neurol. Neurosurg. Psychiatr. · Nov 2003
Biography Historical ArticleCerebral embolism in endocarditis: William Senhouse Kirkes (1823-64).
-
Ion channels provide the basis for the regulation of electrical excitability in the central and peripheral nervous systems. This review deals with the techniques that make the study of structure and function of single channel molecules in living cells possible. These are the patch clamp technique, which was derived from the conventional voltage clamp method and is currently being developed for automated and high throughput measurements; and fluorescence and nano-techniques, which were originally applied to non-biological surfaces and are only recently being used to study cell membranes and their proteins, especially in combination with the patch clamp technique. The characterisation of the membrane channels by techniques that resolve their morphological and physical properties and dynamics in space and time in the nano range is termed nanoscopy.
-
J. Neurol. Neurosurg. Psychiatr. · Nov 2003
The longitudinal relation between brain lesion load and atrophy in multiple sclerosis: a 14 year follow up study.
Studies have suggested that T2 lesion activity is prominent in early relapsing-remitting multiple sclerosis, whereas brain atrophy, while seen early, appears more evident in later progressive disease. The temporal relation between these processes remains unclear. ⋯ From this, it appears that early rather than later focal lesion accumulation relates to subsequent brain atrophy, but factors unconnected directly with lesion formation probably also play a significant role in determining such atrophy.