Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Apr 2003
Biography Historical ArticleFridtjof Nansen (1861-1930).
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J. Neurol. Neurosurg. Psychiatr. · Mar 2003
Comment Comparative Study Clinical TrialA controlled study comparing visual function in patients treated with vigabatrin and tiagabine.
Vigabatrin treatment is frequently associated with irreversible retinal injury and produces retinal electrophysiological changes in nearly all patients. Concern has been raised that tiagabine and other antiepilepsy drugs (AEDs) that increase brain gamma-aminobutyric acid (GABA) might produce similar electrophysiological and clinical changes in visual function. The study compared visual function between groups of patients with epilepsy treated long term with tiagabine, vigabatrin, and patients treated with other AEDs. ⋯ Unlike vigabatrin, tiagabine treatment is associated with normal electroretinography and visual fields and ophthalmological function similar to epilepsy control patients. Differences between vigabatrin and other GABA modulating AEDs in retinal drug concentrations and other effects might explain why tiagabine increases in GABA reuptake do not cause retinal injury.
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J. Neurol. Neurosurg. Psychiatr. · Mar 2003
Biography Historical ArticleAllvar Gullstrand (1862-1930).
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J. Neurol. Neurosurg. Psychiatr. · Mar 2003
Letter Case ReportsChiari I malformation mimicking myasthenia gravis.