Journal of neurology, neurosurgery, and psychiatry
-
J. Neurol. Neurosurg. Psychiatr. · Jan 1975
Comparative StudyA study of sensitivity to curare in myasthenic disorders using a regionaltechnique.
A study of curare sensitivity has been made in ocular myasthenia, myasthenia gravis, and the myasthenic syndrome sometimes associated with carcinoma, using a regional technique. Sensitivity is greater than in normal subjects. ⋯ This sensitivity to curare was not directly related to myasthenic weakness. The reasons for this are discussed and an explanation for such curare sensitivity is suggested.
-
J. Neurol. Neurosurg. Psychiatr. · Oct 1974
Intracranial volume--pressure relationships during experimental brain compression in primates. 3. Effect of mannitol and hyperventilation.
In 10 anaesthetized and ventilated baboons a steady level of raised intracranial pressure was achieved by graduated inflation of an extradural balloon. Measurements were made of the ventricular fluid pressure, and of the change in this pressure after injection of 0·05 ml into the ventricle, the volume-pressure response. ⋯ Mannitol, however, caused a greater reduction in the volume-pressure response than in ventricular fluid pressure. The intravenous administration of mannitol therefore produces a beneficial effect on intracranial capacitance which is greater than observation of intracranial pressure alone indicates.
-
J. Neurol. Neurosurg. Psychiatr. · May 1974
Effects of ergotamine and methysergide on blood platelet aggregation responses of migrainous subjects.
Platelet aggregation responses to 5-hydroxytryptamine (5-HT) were measured in plasma from migrainous subjects taking either methysergide maleate or ergotamine tartrate and were found to be reduced. Blood 5-HT levels of subjects free of headache were not affected by these drugs. The results support the hypothesis that methysergide and ergotamine act by occupying 5-HT uptake sites in vessel walls, leaving 5-HT molecules available to occupy receptors concerned with vasoconstriction.
-
J. Neurol. Neurosurg. Psychiatr. · Feb 1974
Creutzfeldt-Jakob disease: further similarities with kuru.
A typical case of Creutzfeldt-Jakob disease is described. Two unusual morphological features-namely, `kuru-like' plaques in the cerebellum and coarsely vacuolated neurones in the striatum-are further similarities between Creutzfeldt-Jakob disease and kuru.
-
J. Neurol. Neurosurg. Psychiatr. · Jan 1974
Mixed or immune complex cryoglobulinaemia and neuropathy.
Three patients with peripheral neuropathy and mixed or immune complex cryoglobulinaemia are reported. The significance of mixed cryoglobulinaemia and the pathogenesis of the peripheral neuropathy are discussed.