European journal of clinical investigation
-
Eur. J. Clin. Invest. · Sep 2019
Impact of platelet turnover on long-term adverse cardiovascular outcomes in patients undergoing percutaneous coronary intervention.
Increased platelet turnover and high platelet reactivity are associated with short-term major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) or stable coronary artery disease (SCAD). We investigated the impact of platelet turnover on long-term MACE. ⋯ Increased platelet turnover is associated with long-term adverse outcome in patients with coronary artery disease undergoing PCI. Platelet turnover represents a new marker of atherothrombotic risk and might help to guide composition or duration of antiplatelet therapy.
-
Eur. J. Clin. Invest. · Sep 2019
Meta AnalysisNonalcoholic fatty liver disease increases the risk of gastroesophageal reflux disease: A systematic review and meta-analysis.
Increasing evidence indicates that nonalcoholic fatty liver disease (NAFLD) is linked to an increased risk of extra-hepatic conditions. However, it is currently uncertain whether NAFLD is associated with the risk of gastroesophageal reflux disease (GERD). We performed a systematic review and meta-analysis of relevant studies to examine the association between NAFLD and the risk of GERD. ⋯ NAFLD is associated with an increased risk of GERD. However, future large and cohort studies are still needed to determine the causal relationship between NAFLD and the risk of GERD.
-
Eur. J. Clin. Invest. · Sep 2019
Meta AnalysisUric acid level, gout and bone mineral density: A Mendelian randomization study.
This study aimed to examine whether the uric acid level or gout is causally associated with bone mineral density (BMD). ⋯ Mendelian randomization analysis did not support a causal association between uric acid level, gout and lumbar spine or FN BMD.
-
Eur. J. Clin. Invest. · Sep 2019
Risk stratification of elderly patients with acute pulmonary embolism.
Combining high-sensitivity cardiac Troponin T (hs-cTnT), NT-pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP) may improve risk stratification of patients with pulmonary embolism (PE) beyond the PESI risk score. ⋯ In elderly patients with PE, 6-month mortality can adequately be predicted by the PESI risk score alone.
-
Eur. J. Clin. Invest. · Sep 2019
Low serum magnesium and 1-year mortality in alcohol withdrawal syndrome.
In 2014, the WHO reported that 6% of all deaths were attributable to excess alcohol consumption. The aim of the present study was to examine the relationship between serum magnesium concentrations and mortality in patients with alcohol withdrawal syndrome (AWS). ⋯ Overall, 1-year mortality was significantly higher among those patients who were magnesium deficient (<0.75 mmol/L) when compared to those who were replete (≥0.75 mmol/L; P < 0.001).