European journal of clinical investigation
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Eur. J. Clin. Invest. · Apr 2020
Relative risks and odds ratios: Simple rules on when and how to use them.
Relative risks and odds ratios are widely reported in the medical literature, but can be very difficult to understand. We sought to further clarify these important indices. ⋯ Understanding the difference between relative risks and odds ratios and when and how to use them may aid clinical interpretation, dissemination and translation of research findings.
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Eur. J. Clin. Invest. · Apr 2020
Review Meta AnalysisGenetic variations in MicroRNA genes and cancer risk: A field synopsis and meta-analysis.
Cancer risk has been associated with certain gene variations in microRNA (miRNA), but conflicting evidence warrants re-assessing of significant results in meta-analyses. We summarized published meta-analyses that assess the associations between miRNA polymorphism and cancers to show the validity of the findings. ⋯ Out of 68 published associations of miRNA polymorphisms with cancer, sixteen have shown noteworthiness in our re-assessing meta-analysis. Our findings summarize the results of meta-analyses on the association of cancer with SNPs and underline the importance of interpreting results with caution.