European journal of clinical investigation
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Eur. J. Clin. Invest. · Jun 2021
Initial experience with percutaneous mitral valve repair in patients with cardiac amyloidosis.
Percutaneous mitral valve repair (PMVR) is a therapeutic option for severe mitral regurgitation (MR) in patients with heart failure due to differential aetiologies. However, only little is known about the safety and efficacy of this procedure in patients with amyloid cardiomyopathy. ⋯ PMVR is a feasible and safe procedure in patients with cardiac amyloidosis and might carry a possible survival benefit in this patient group.
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Eur. J. Clin. Invest. · Jun 2021
CircWHSC1 serves as an oncogene to promote hepatocellular carcinoma progression.
Circular RNAs (circRNAs) function as vital regulators in multifarious cancers, including hepatocellular carcinoma (HCC). However, the roles of circRNA Wolf-Hirschhorn syndrome candidate gene-1 (circWHSC1) in HCC are barely known. ⋯ CircWHSC1 played a tumour-promoting role in HCC by elevating HOXA1 through sponging miR-142-3p.
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Eur. J. Clin. Invest. · Jun 2021
The Relationship Between Serum Uric Acid Levels and Development of Obesity in Living Kidney Donors After Donor Nephrectomy.
Hyperuricaemia plays a role in the pathogenesis of obesity and related metabolic disorders. The aim of this study to investigate the relationship between pre-donation serum uric acid (SUA) level and obesity development after nephrectomy in living kidney donors. ⋯ Living kidney donors (LKD) have a tendency to obesity after nephrectomy. Preoperative serum uric acid level gives important information in LKDs that it could foresee the development of obesity after donation.
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Eur. J. Clin. Invest. · Jun 2021
Observational StudyCardiac troponin and COVID-19 severity: results from BIOCOVID study.
Myocardial injury is a common finding in COVID-19 strongly associated with severity. We analysed the prevalence and prognostic utility of myocardial injury, characterized by elevated cardiac troponin, in a large population of COVID-19 patients, and further evaluated separately the role of troponin T and I. ⋯ In this multicentre study, myocardial injury was a common finding in COVID-19 patients. Its prevalence increased when a sex-specific cut-off and cardiac troponin T were used. Elevated troponin was an independent predictor of 30-day mortality, irrespective of cardiac troponin assay and cut-offs to detect myocardial injury. Hence, the early measurement of cardiac troponin may be useful for risk stratification in COVID-19.