European journal of clinical investigation
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As a powerful anti-inflammatory, immunosuppressive, and antiproliferative drug, glucocorticoid (GC) plays an important role in the treatment of various diseases. However, some patients may experience glucocorticoid resistance (GCR) in clinical, and its molecular mechanism have not been determined. ⋯ The molecular mechanisms of GCR are complex and may differ in different diseases or different patients. In future studies, when exploring the mechanism of GCR, methods to improve GC sensitivity should also be investigated.
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Eur. J. Clin. Invest. · Feb 2023
Improving risk prediction for death, stroke, and bleeding in Asian patients with atrial fibrillation.
The objectives of this study were to compare the GARFIELD Refitted model and CHA2 DS2 -VASc/HAS-BLED risk scores with the new model from the COOL-AF registry for all-cause death, ischaemic stroke/systemic embolism (SSE) and major bleeding in Asian patients with atrial fibrillation (AF). ⋯ The COOL-AF predictive models for all-cause mortality, SSE and major bleeding in Asian patients with AF had a good predictive ability. The COOL-AF model for all-cause mortality was superior to the GARFIELD Refitted and CHA2 DS2 -VASc model.
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Eur. J. Clin. Invest. · Feb 2023
Observational StudyAssociation between right ventricular dysfunction and adverse cardiac events in mild COPD patients.
Lung hyperinflation and systemic inflammation are currently believed to be the most important causes of right heart alterations in chronic obstructive pulmonary disease (COPD) patients. A multicentre observational study was performed to assess the morphological and functional parameters of right ventricle (RV) in COPD subjects, as well as to evaluate the potential prognostic impact on the development of major cardiovascular adverse events (MACEs). ⋯ The results of this study showed that in patients with mild COPD there is an association between right heart dysfunction and the risk of MACE during follow-up.