European journal of clinical investigation
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Eur. J. Clin. Invest. · Jun 2023
Estimated glomerular filtration rate, haemodynamics, and mortality in patients with aortic stenosis.
In aortic stenosis (AS), estimated glomerular filtration rate (eGFR) is an important prognostic marker but its haemodynamic determinants are unknown. We investigated the correlation between eGFR and invasive haemodynamics and long-term mortality in AS patients undergoing aortic valve replacement (AVR). ⋯ In patients with AS, low eGFR is a marker of an unfavourable haemodynamic constellation as well as important co-morbidities. This may in part explain the association between low eGFR and increased post-AVR mortality.
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Eur. J. Clin. Invest. · Jun 2023
Global, regional, and national burden of alopecia areata and its associated diseases, 1990-2019: a systematic analysis of the Global Burden of Disease Study 2019.
No study to date has concomitantly reported the global burden of alopecia areata (AA) and its associated diseases. ⋯ The burden of AA was prominent in females, young adults, high sociodemographic countries and North Americans. The study corroborates sex- and region-specific implications and public health measures for AA and its associated burdens. These epidemiological data on AA burden can guide future research efforts, prevention strategies and allocation of resources.
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Eur. J. Clin. Invest. · Jun 2023
The miR-29 family members induce glioblastoma cell apoptosis by targeting cell division cycle 42 in a p53-dependent manner.
Emerging evidence has shown that miR-29 is a promising biomarker and therapeutic target for malignancies. The roles of miR-29a/b/c in glioma pathogenesis remain need further investigation. ⋯ miR-29a/b/c are independent predictors of prognosis in glioma patients. They induce glioblastoma cell apoptosis via silencing of CDC42 and suppression of downstream PAK/AKT/MDM2 signalling in a p53-dependent manner.