European journal of clinical investigation
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Eur. J. Clin. Invest. · Aug 2023
Changes in biomarkers of endothelial function, oxidative stress, inflammation and lipids after smoking cessation: a cohort study.
Tobacco use is known to be involved in the development of cardiovascular diseases, which leads to premature mortality. Endothelial dysfunction, the first step in this process, was shown induced by smoking. It is reported that quitting smoking could reduce the risk of diseases, but the implied mechanisms are still unclear. This study aimed to evaluate the biological markers of endothelial function in smokers when actively smoking and after cessation. ⋯ These observations suggest that some adverse effects of smoking on endothelial function could be reversible on quitting smoking. It could encourage smokers to enter a cessation program to reduce the risk for cardiovascular diseases development.
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Eur. J. Clin. Invest. · Aug 2023
Association between sleep traits and primary liver cancer: A Mendelian randomization analysis.
Primary liver cancer (PLC) is the sixth most frequently occurring cancer, representing one of the top 5 leading causes of cancer-related mortality worldwide. Recently, researchers have focused more on the impact of living habits on the incidence and development of tumours. This study reports a relationship between sleep traits and PLC. ⋯ Overall, our study indicates that insomnia and nap during the day may be risk factors of PLC and adequate night sleep might keep us away from PLC.
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Eur. J. Clin. Invest. · Aug 2023
Rebooting Disruptive Science: Exploring the challenges and potential solutions.
There has been a decline in the number of disruptive scientific discoveries and breakthroughs. Here, reasons for the decline of disruptive science are explored including declining funding for basic research, increasing risk-aversion among scientists, pressure to publish quickly and increasing administrative workload. Solutions are proposed to reverse the trend and encourage disruptive research especially for young scientists.
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Eur. J. Clin. Invest. · Aug 2023
Modified Rapid Emergency Medicine Score-Lactate (mREMS-L) performance to screen non-anticipated 30-day related-mortality in Emergency Department.
The aim of this study was to compare the ability to predict 30-day in-hospital mortality of lactate versus the modified Rapid Emergency Medicine Score (mREMS) versus the arithmetic sum of the mREMS plus the numerical value of lactate (mREMS-L). ⋯ The new score generated, mREMS-L, obtained better statistical results than its components (mREMS and lactate) separately.