Lancet
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Review Meta Analysis Comparative Study
Selective oestrogen receptor modulators in prevention of breast cancer: an updated meta-analysis of individual participant data.
Tamoxifen and raloxifene reduce the risk of breast cancer in women at elevated risk of disease, but the duration of the effect is unknown. We assessed the effectiveness of selective oestrogen receptor modulators (SERMs) on breast cancer incidence. ⋯ Cancer Research UK.
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The nuclear transcription factor c-Jun is preferentially expressed in basal-cell carcinoma. Dz13 is a deoxyribozyme that targets JUN messenger RNA and has inhibited the growth of a range of tumours in mice. We did a phase 1 study to assess safety and tolerability in human beings. ⋯ Cancer Institute NSW, Cancer Council Australia, and National Health and Medical Research Council.