Lancet
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Review Meta Analysis
Epilepsy in pregnancy and reproductive outcomes: a systematic review and meta-analysis.
Antenatal care of women with epilepsy is varied. The association of epilepsy and antiepileptic drug exposure with pregnancy outcomes needs to be quantified to guide management. We did a systematic review and meta-analysis to investigate the association between epilepsy and reproductive outcomes, with or without exposure to antiepileptic drugs. ⋯ EBM CONNECT Collaboration.
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Randomized Controlled Trial Multicenter Study Comparative Study
Fractional flow reserve versus angiography for guidance of PCI in patients with multivessel coronary artery disease (FAME): 5-year follow-up of a randomised controlled trial.
In the Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) study, fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) improved outcome compared with angiography-guided PCI for up to 2 years of follow-up. The aim in this study was to investigate whether the favourable clinical outcome with the FFR-guided PCI in the FAME study persisted over a 5-year follow-up. ⋯ St Jude Medical, Friends of the Heart Foundation, and Medtronic.
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Randomized Controlled Trial Multicenter Study
Early combined immunosuppression for the management of Crohn's disease (REACT): a cluster randomised controlled trial.
Conventional management of Crohn's disease features incremental use of therapies. However, early combined immunosuppression (ECI), with a TNF antagonist and antimetabolite might be a more effective strategy. We compared the efficacy of ECI with that of conventional management for treatment of Crohn's disease. ⋯ AbbVie Pharmaceuticals.