Lancet
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Rectal bleeding and endoscopy need in Sierra Leone: results of a nationwide, community-based survey.
Low-income and middle-income countries (LMICs) face a large burden of gastrointestinal diseases that benefit from prompt endoscopic diagnosis and treatment. This study aimed to estimate the prevalence of gross rectal bleeding among adults in Sierra Leone. ⋯ Surgeons OverSeas, the Thompson Family Foundation, and the Fogarty International Center.
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A safe and sufficient blood supply is requisite for a functional surgical system. Although the disparity in blood donation rates between low-income and middle-income countries (LMICs) and high-income countries is well documented, less is known about the reasons for this inequity, which compromises efforts to remedy it. We aimed to review the state of the blood supply and elucidate unique country-specific challenges in each of the world's 196 countries. ⋯ None.
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Randomized Controlled Trial Multicenter Study
Rituximab as second-line treatment for adult immune thrombocytopenia (the RITP trial): a multicentre, randomised, double-blind, placebo-controlled trial.
Immune thrombocytopenia is characterised by immune-mediated destruction and suboptimum production of platelets. Despite the absence of supporting evidence, rituximab is frequently used off-label in patients with immune thrombocytopenia. We aimed to assess the efficacy of rituximab as compared with placebo as a splenectomy-sparing treatment in patients who were previously treated with corticosteroids. ⋯ South-East Regional Health Authority and Østfold Hospital, Norway; Roche, France; and Roche, Norway.
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Randomized Controlled Trial Multicenter Study
Central arteriovenous anastomosis for the treatment of patients with uncontrolled hypertension (the ROX CONTROL HTN study): a randomised controlled trial.
Hypertension contributes to cardiovascular morbidity and mortality. We assessed the safety and efficacy of a central iliac arteriovenous anastomosis to alter the mechanical arterial properties and reduce blood pressure in patients with uncontrolled hypertension. ⋯ ROX Medical.