Lancet
-
Transarterial chemoembolisation (TACE) is still widely used to treat patients with advanced hepatocellular carcinoma who have no access to sorafenib in Asia. However, the indication of TACE for these patients has yet to be established. We established an objective point score to guide this decision in patients with advanced-stage hepatocellular carcinoma. ⋯ This study was supported by grants from the National Natural Science Foundation of China (81172037/H1606, 81272639, and 81572385), Guangdong province science and technology project of China (2013B021800159), and the Fundamental Research Funds for the Central Universities of China (13ykzd24).
-
Recent studies on MRI-based discrimination of schizophrenia have shown promise. Considering that, in general, pathological changes should display characteristic markers in both brain function and anatomy, machine-learning methods using multimodal MRI features of brain networks might provide a deeper insight into the pathological mechanism of schizophrenia. We aimed to assess the discriminative power of multimodal MRI features and to extract these features of high discriminative information for classification of patients with schizophrenia. ⋯ National Natural Science Foundation of China (81401473). Data collection by the Mind Research Network was funded by a Center of Biomedical Research Excellence (COBRE) grant (5P20RR021938/P20GM103472) from the National Institutes of Health.
-
Despite well-established benefits of exercise in the management of metabolic syndrome, evidence to support exercise adherence after program completion is lacking. We used a smartphone-based exercise adherence intervention (Virtual Trainer; Ex-VT) for adults with metabolic syndrome in Hong Kong, China. The objectives were to measure the feasibility, potential effectiveness, and implementation of Ex-VT in sustaining prescribed exercise practice for risk reduction in metabolic syndrome. ⋯ Departmental Research Fund, Cardiac and Acute Care Research Theme Group, The Nethersole School of Nursing, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China (CV1502).
-
Physician motivation to maintain public welfare has become the key for the New Public Hospital Reform in China. This study aimed to apply a different perspective, the psychological contract (a popular concept in business management research) and explore the correlations between physicians' psychological contract and their job satisfaction, intention to leave medical practice, and professionalism. ⋯ This study was supported by the National Natural Science Foundation of China (Grant number 71203032), and the Shanghai Planning Project of Philosophy and Social Science (Grant number 2014EGL005).
-
Periconceptional folic acid use has been widely recommended to reduce risk of neural tube defects. However, the effect on other birth defects and adverse pregnancy outcomes, as well as the time window of folic acid use, needs further investigation. Our study aimed to comprehensively assess the effect of periconceptional folic acid use on pregnancy outcomes in a mega-cohort of women of reproductive age. ⋯ Five-twelfth National Science and Technology Support Program (number 2013BAI12B01), the operation funds for basic scientific research of the central authorities (number 2015GJM09). We are thankful for the support of all the investigators and participants who contributed to the National Free Preconception Health Examination Project.