Lancet
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Case Reports Clinical Trial Controlled Clinical Trial
Naloxone, a specific opioid antagonist, reverses chronic idiopathic constipation.
Two patients with long-standing idiopathic chronic constipation, which responded only to large daily doses of laxatives and additional suppositories and enemas, were treated with the specific opioid antagonist, naloxone, on a single-blind crossover basis. Both patients responded to naloxone treatment, with increased passage of faeces and increased wet and dry faecal weight. Although naloxone is poorly absorbed after oral administration, there was a positive response during oral as well as intravenous treatment, suggesting that the primary effect of naloxone is at specific opiate receptor sites in the myenteric plexus and other neural and endocrine cells of the intestinal wall.
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Historical Article
A coordinated approach to children's health in India: progress report after five years (1975-1980).
The success of an experiment in a coordinated approach to children's health care in India in 33 community blocks led to its expansion to a national programme covering 150 community blocks by 1980. The Integrated Child Development Services (ICDS) scheme has also been successful as a national programme. ⋯ Favourable impact of ICDS services was proportionally better in the first year than in the fourth year of the service. The Government of India has declared it a programme of national importance to expand and cover 913 of the 5011 community blocks and 87 urban slum areas by 1985.
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Letter Randomized Controlled Trial Clinical Trial
"Starch blockers" are ineffective in man.