The Medical clinics of North America
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The phenomenology of OCD and TS seem to match perfectly with the existing conceptualization of the functional relationship between frontal cortical and subcortical circuits. Failed editing of thoughts and impulses, perseverative patterns, and inhibitory deficits are the most convenient descriptors of the symptoms, and some operationalized measures can capture evidence for such deficits in TS and OCD patients. ⋯ This is not a criticism of the existing studies of TS and OCD; to the contrary, the scarcity of pathologic material, the limits of resolution of existing technologies, and the heterogeneity of the phenotypes make the accomplishments of these studies more impressive. As clinicians strive to integrate clinical and scientific findings into coherent models for the pathophysiology of OCD and TS, it is useful to identify practical and effective strategies for therapeutic interventions.
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In 1990s, it was found that GSAD is more common, more disabling, and more chronic than previously realized. For the first time, there are good data about a range of effective treatment options that can offer these patients substantial relief and protection from their disability.
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Atrial fibrillation is a common cardiac arrhythmia with significant sequela. The goals of treating atrial fibrillation are rate control, prevention of thromboembolism, and maintenance of sinus rhythm. The epidemiology and pathophysiology of atrial fibrillation is reviewed, as well as strategies and recommendations for achieving therapeutic goals. The authors also review investigational therapeutic options using nonpharmacologic modalities.
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Med. Clin. North Am. · Mar 2001
ReviewPolymorphic ventricular tachycardia, long Q-T syndrome, and torsades de pointes.
PMVT is an uncommon arrhythmia with multiple causes. Classification and management are based on the Q-T interval. ⋯ Evaluation of these patients should include a thorough history and physical examination and an assessment for underlying heart disease and known [figure: see text] eliciting factors. Long-term management must be tailored to the individual and the underlying cause and should be conducted by an experienced cardiac electrophysiologist.
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Med. Clin. North Am. · Jul 2000
ReviewAdvances in medical management of asthma, headaches, and fatigue.
The 1990s in medicine have been characterized by the development of various clinical guidelines to assist in the diagnosis, classification, and management of common disorders. Among the most frequent presenting complaints of adolescent patients are asthma, headaches, and fatique. In an era of managed care and brief clinical encounters, application of standardized guidelines, modified appropriately for adolescents, is likely to improve clinical outcomes, including patient and parent satisfaction. In each of these disorders, engaging the adolescent patient as a partner in planning and implementing management is crucial to success.