Medicine
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Advanced studies demonstrated that hypoxic stress induced KIAA1199 expression leading to enhanced cell migration. KIAA1199 is a protein related with cancer metastasis. Hypoxia inducible factor 1α (HIF-1α) is a transcriptional factor that maintains oxygen homeostasis. ⋯ In survival analysis, KIAA1199(H)/HIF-1α(H) patients had the worst prognosis. Using the combination of the two parameters increased the prognostic value (P < .01 vs P = .03). KIAA1199 in combination with HIF-1α expression tends to indicate a more accurate prognosis.
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Observational Study
Constructing a new health education model for patients with chronic hepatitis B.
To explore the effects of the project-achievement quality control circle in constructing a new health education model for patients with chronic hepatitis B. The quality control circle group was established and the theme of "constructing a new health education model for patients with chronic hepatitis B" was selected. ⋯ The awareness of health education increased from 71.90 ± 13.48 to 95.60 ± 2.84 points (P < .001), the satisfaction rate of health education increased from 76.60 ± 8.71 points to 98.00 ± 2.03 points (P < .001), and the evaluation rate after health education increased from 10% to 100% (P < .001). The circle members have much more confidence in quality control circle activities, the use of techniques, and the knowledge related to scientific research.
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Observational Study
Medication utilization evaluation of androgen deprivation therapy for prostate cancer in Taiwan.
Prostate cancer is one of the most common cancer in males. Both the incidence and the mortality rates of prostate cancer show an increasing trend. Androgen deprivation therapy (ADT) is the standard treatment for metastatic prostate cancer. ⋯ Bicalutamide was the second most used drug from 2008 to 2015, but its utilization was not different for different stages. The incidence rate of prostate cancer increased in the study period and medical expenditure also increased in ADT treatment. Health insurance benefits for various ADT drugs should be further evaluated.
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There is evidence that intake of proton pump inhibitors (PPI) increases the risk for spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis. However, data regarding the impact of PPI intake on occurrence of infections other than SBP are still lacking. We hypothesized that PPI use is associated with a higher rate of infections other than SBP in patients with liver cirrhosis. ⋯ Pantoprazole and omeprazole were the most frequently prescribed PPIs and were both independently associated with the occurrence of infections. PPI use may be associated with infections other than SBP in patients with liver cirrhosis. Prescription of PPI should be limited to patients with a clear indication.
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Observational Study
Assessment of the content, usability, and benefits of the WeChat-based programme for dog bite victims in China: A prospective observation study.
WeChat in China has been used for public health education and the prevention of diseases. This study introduced a WeChat-based program for rabies prevention and evaluated the users' satisfaction with the program using the technology acceptance model. An online satisfaction questionnaire was used to survey 315 users who had followed the WeChat official account in China, and their satisfaction scores were assessed and analyzed. ⋯ Users who were satisfied also reported that they intended to recommend WeChat to others (P = .00). Findings from the present study indicated that WeChat was considered a useful educational and instructional tool for dog-bite victims among young and urban population. This model of a WeChat-based program for rabies prevention should be expanded to other areas in China.