Medicine
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Previous studies demonstrated that ADRB3, beta-3 adrenergic receptor, participated in lipolysis and thermogenesis in adipose tissue. Consequently, this gene has attracted an increasing number of genetic studies examining its association with coronary artery disease (CAD) in different ethnicities in recent years, but no conclusion has been reached so far. The aim of this study was to explore whether the well-studied locus ADRB3 Trp64Arg in this gene confers a race-specific effect to CAD by conducting a stratified meta-analysis involving 15 independent studies and 11,802 subjects. ⋯ This meta-analysis suggests that ADRB3 Trp64Arg polymorphism confers a race-specific effect to CAD.
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The methylenetetrahydrofolate reductase (MTHFR) may play a pathological role in polycystic ovary syndrome (PCOS). However, the conclusions of published reports on the relationship between the MTHFR C677T polymorphism and PCOS risk remain controversial. To derive a more precise estimation we performed a metaanalysis based on 22 studies that together included 2405 cases and 2419 controls. ⋯ Metaanalysis results showed a significant association between the MTHFR C677T polymorphism and PCOS risk in 3 genetic models (allele model: OR = 1.40, 95% CI = 1.27-1.53; dominant model: OR = 1.47, 95% CI = 1.17-1.85); homozygous model: OR = 1.90, 95% CI = 1.55-2.32). Moreover, significant associations were observed when stratified by ethnicity, source of controls, etiology, and genotype methods. This metaanalysis suggests that the T-allele of the MTHFR C677T polymorphism is associated with an increased risk of PCOS, especially in Asians further studies with larger population sizes are needed to confirm these results.
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The surgical management of acute malignant left-sided bowel obstruction is associated with high morbidity and mortality. Recently, transanal drainage tubes (DTs) and metallic stents (MSs) used as a "bridge to surgery" have become widely used decompression methods compared with emergency surgery. This study aims to evaluate the efficacy and safety of DTs and MSs for the decompression of acute left-sided malignant colorectal obstruction. ⋯ MS insertion for acute left-sided malignant bowel obstruction is effective and safe with a better technical success rate and with fewer complications than decompression using a DT, and MS insertion can avoid stoma formation. Moreover, MS insertion appears to be a useful treatment strategy for malignant colonic obstruction even if the lesion is located in the right colon. More large-sample, multicenter, high-quality RCTs are needed to verify the outcomes of this meta-analysis.
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Meta Analysis
Association between interleukin-10 -1082A/G polymorphism and risk of ischemic stroke: A meta-analysis.
The Interleukin-10 -1082A/G polymorphism has been indicated to be correlated with ischemic stroke susceptibility, but the results of studies are still debatable. Thus, a meta-analysis was carried out. Databases including PubMed, Embase, and CNKI were searched. ⋯ Meanwhile, similar results were also observed in matched studies, hospital-based subgroup, Asians, and large sample-size studies. In conclusion, this meta-analysis suggested that the IL-10 -1082A/G polymorphism contributes to decreased ischemic stroke risk. Further large-scale and well-designed studies are still needed to confirm the results of our meta-analysis.
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Meta Analysis
Association of rs2230806 in ABCA1 with coronary artery disease: An updated meta-analysis based on 43 research studies.
As a key gene in the reverse transport pathway of cholesterol, ABCA1 (ATP-binding cassette transporter A1) plays an important role in the pathogenesis of coronary artery disease (CAD). In the ABCA1, rs2230806 is the most widely studied polymorphism and its role has been controversial. ⋯ The K allele of rs2230806 was significantly associated with decreased risk of CAD, especially in Asian populations and small sample Caucasians.