Medicine
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Long noncoding RNAs (lncRNAs) can act as microRNA (miRNA) sponges to regulate protein-coding gene expression; therefore, lncRNAs are considered major components of the competitive endogenous RNA (ceRNA) network and have attracted growing attention. This study explored the regulatory mechanisms and functional roles of lncRNAs as ceRNAs in the malignant differentiation of low-grade glioma (LGG) to glioblastoma (GBM) and their potential impact on the prognosis of patients with GBM. ⋯ The proposed ceRNA network may help elucidate the regulatory mechanism by which lncRNAs function as ceRNAs and contribute to the malignant differentiation of LGG to GBM. Importantly, the candidate lncRNAs, miRNAs, and mRNAs involved in the ceRNA network can be further evaluated as potential therapeutic targets and prognostic biomarkers for GBM.
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Observational Study
A new peak-power estimation equations in 12 to 14 years-old soccer players.
The aim of this study was to develop an age and soccer-specific regression equation to estimate the peak power of children aged 12-14 from the height of their vertical jumps using a large sample (n = 188). This study included 188 male soccer players (age, 12.6 ± 0.55; height, 153.31 ± 8.38 cm; and body weight, 43.65 ± 7.58 kg). Their actual peak power values obtained from vertical jumps were recorded using a force platform. ⋯ Actual peak power is highly predictable for 12-14-year-old football players. In line with the new model, the actual peak power values obtained in this study were close to the estimated peak power values obtained with the Tufano formula. This may be because of the larger sample size and the same branch used for both equation models.