Medicine
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Case Reports
Clinical assessment and FGFR2 mutation analysis in a Chinese family with Crouzon syndrome: A case report.
Crouzon syndrome is an autosomal dominant genetic disorder caused by mutations in fibroblast growth factor receptor 2 (FGFR2) and one of the most common types of craniosynostosis. Here we report the detection of FGFR2 mutation and its related clinical findings in 2 patients with Crouzon syndrome from a Chinese family. ⋯ Our study confirms the presence of optic nerve atrophy in patients with Crouzon syndrome carrying FGFR2 C342W mutations and indicates that MRI and funduscopy should be performed to examine the optic nerve changes for patients with Crouzon syndrome.
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Observational Study
Relationships between serum omentin-1 concentration, body composition and physical activity levels in older women.
This study aimed to investigate the relationships between omentin-1, body composition and physical activity (PA) levels in older women. Eighty-one older women (age = 64 ± 6years; body mass index = 24.2 ± 3.2 kg/m2; body fat percentage = 36.1 ± 5.7%) participated in this study. We divided the subjects into overweight/obesity and normal weight group. ⋯ We found that total body FM was inversely related to serum omentin-1 concentration and PA levels, but there was no correlation between omentin-1 and PA levels. These results showed that PA may participate in the regulation of body composition, which may be also affected by serum omentin-1. However, the mechanism by which PA affects body composition may not be through omentin-1 and was more likely through other metabolic pathways.
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Case Reports
Necrotizing fasciitis secondary to lake water inoculation with Aeromonas sobria: A case report.
Necrotizing fasciitis (NF) is a rapidly progressing bacterial soft tissue infection with a high mortality rate. It is characterized by significant soft tissue destruction with associated sepsis. The mainstay of treatment is coverage with appropriate broad-spectrum antibiotic therapy and emergent surgical debridement. ⋯ Close monitoring for NF is important for tissue infections sustained in aquatic environments. Timely identification and surgical management of NF increases overall survival.
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The aim of this study was to discuss the correlation between the sulfamethoxazole-trimethoprim resistance of Shigella flexneri (S. flexneri) and the antibiotic resistance genes sul1, sul2, and sul3 and SXT element. From May 2013 to October 2018, 102 isolates of S. flexneri were collected from the clinical samples in Jinan. The Kirby-Bauer (K-B) test was employed to determine the antibiotic susceptibility of the S. flexneri isolates. ⋯ The sul3 gene and SXT element were not amplified from any of the isolates. The testing and statistical analysis showed that the resistance of the S. flexneri isolates to sulfamethoxazole-trimethoprim correlated to the sul1 and sul2 genes. The acquired antibiotic resistance genes sul1 and sul2 were closely associated with the resistance of the 102 S. flexneri isolates to sulfamethoxazole-trimethoprim.
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Inflammatory bowel disease (IBD) has emerged in the Asia-Pacific area over the past 2 decades. There is a paucity of clinical data regarding real-world experience of patients with IBD from low endemic area such as Taiwan. Therefore, the present study aimed to review the clinical features of patients with IBD form a tertiary center from Taiwan. ⋯ A trend of decreased bowel resection for patients with IBD and less severe phenotype of patients with CD were observed after 2015. UC with male predominance was the predominant type of IBD in the study. Patients with CD are likely to have a complicated disease course, requiring a higher demand of biologic therapy than patients with UC.