Medicine
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Fetal lung adenocarcinoma (FLAC) is a rare malignant tumor that occurs in the alveolar epithelium. FLAC, as a distinct entity, is a malignancy with a very low incidence, accounting for less than 0.5% of all lung tumors, with a high rate of misdiagnosis due to its rarity, lack of typical presentation and imaging signs. According to histopathological differences, FLAC is further divided into 2 types: low-grade FLAC and high-grade FLAC. In the article, we report a young woman who was diagnosed with low-grade fetal-type lung adenocarcinoma. ⋯ To the best of our knowledge, there are no previous case reports of low-grade fetal-type adenocarcinoma, TP53 gene mutation, and the significance of its mutation is not extensively studies. FLAC, although extremely rare, is considered in the differential diagnosis of lung cancer. In addition, biopsy, histopathology, and specific immunohistochemical staining of larger tissue specimens are helpful for accurate diagnosis of FLAC.
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Heart failure with preserved ejection fraction (HFpEF) comprises about 50% of the cases of heart failure (HF), but so far there is no effective treatment strategy. This study used bibliometric methods to analyze the scientific literature on HFpEF in 2009 to 2020, and evaluate the global scientific output of HFpEF research, in order to explore the research status and trends in this field. ⋯ Due to the multi-dimensional bibliometric analysis, this study shows a wide view of scientific productivity related to HFpEF, and provides valuable guidance for researchers interested in HFpEF, assisting them in understanding the research status, identifying potential collaborators, discovering research hotspots and frontiers, and conducting more in-depth research.
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This study aimed to explore candidate genes and their potential interaction mechanism critical to the pathophysiology of Turner syndrome by using the Gene Expression Omnibus database. ⋯ In this study, 733 DEGs and 10 hub genes were identified. They would be new candidate targets in Turner syndrome.
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Numerous studies have identified factors related to nurses’ intention to leave. However, none has successfully predicted the nurse’s intention to quit the job. Whether the intention to quit the job can be predicted is an interesting topic in healthcare settings. A model to predict the nurse’s intention to quit the job for novice nurses should be investigated. The aim of this study is to build a model to develop an app for the automatic prediction and classification of nurses’ intention to quit their jobs. ⋯ We performed ANN on Microsoft Excel, which is rare in the literature. An app was built to display results using a visual dashboard on Google Maps. The animation-featured dashboard was incorporated with the ANN model, allowing an easy understanding of the classification results with visual representations. The category probability curves were uniquely derived from the Rasch rating scale model and launched to the ANN prediction model to display the binary classification, using probability to interpret the prediction results.
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To determine the prevalence of prehypertension (PH) and hypertension (AH) in quilombola children and adolescents, as well as to analyze sociodemographic, behavioral, and health characteristics. Prevalence study conducted in random samples of quilombola children and adolescents from 06 to 19 years of age, in remaining quilombo communities in Cachoeira-Bahia. Identification, sociodemographic, behavioral, anthropometric, and blood pressure (BP) data were used. ⋯ Normotensive children and adolescents, and those with alterations in BP differed only in terms of the Body Mass Index (P = .007) and WHtR (P < .001). The consumption of unhealthy foods was high. The high prevalence of PH and AH, as well as of exposure to potential risk factors for AH in quilombola children and adolescents, reveals a worrisome situation, and demands further studies to identify risk factors for this disease and the need for interventions beyond the health sector, especially as regards disease prevention and control in the early stages of life, aiming to reduce its prevalence as adults.