Medicine
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This study aimed to determine the level of brain activation in separate regions, including the lobes, cerebellum, and limbic system, depending on the weight of an object during elbow flexion and extension exercise using functional magnetic resonance imaging (fMRI). The study was conducted on ten male undergraduates (22.4 ± 1.2 years). The functional images of the brain were obtained using the 3T MRI. ⋯ For holding an object in hand, compared to not holding it, the exercise load was greater for controlling the motion to maintain the posture (arm angle at 90°), controlling the speed to repeat the motion at a constant speed, and producing an accurate posing. Therefore, to maintain such varied conditions, the activation level increased in the regions associated with control and regulation through the motion coordination from vision to arm movements (control of muscles). A characteristic reduced activation was observed in the regions associated with visuo-vestibular interaction and voluntary movement when the exercise involved lifting a 1000-g object compared to the exercise without object lifting.
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Extranodal nature killer/T-cell lymphoma (ENKTL) failing in asparaginase-containing treatments is fatal, it has a higher mortality rate when accompanied by secondary hemophagocytic lymphohistiocytosis (HLH). The study reported 2 ENKTL-related HLH patients. ⋯ ENKTL-related HLH needs early diagnosis and treatment. The combined strategy of sintilimab plus chidamide help deal with HLH and solve ENKTL, it may be a useful treatment option for ENKTL-related HLH.
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Meta Analysis
Regional block anesthesia for adult patients with inguinal hernia repair: A systematic review.
Inguinal hernia repair (IHR) is a common surgical technique performed under regional block anesthesia (RBA). Although previous clinical trials have explored the effectiveness and safety of RBA for IHR, no systematic review has investigated its effectiveness and safety in adult patients with IHR. ⋯ The results of this study demonstrated that IHR patients with RBA benefit more from post-surgery pain relief at 24h and a decrease in the ORUCR than those with CSA.
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In December 2019, a new disease, coronavirus disease (COVID-19), emerged, which put several countries on a state of alert. Because it is a novel virus, several aspects and factors that contribute to the evolution of pathogenesis are still unknown and need to be better understood. Therefore, a systematic review is necessary to investigate the association between COVID-19 infection and chronic nontransmissible disease in patients who have died of COVID-19. ⋯ This review revealed a high percentage of comorbidities in the patients with COVID-19, especially those who died.
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Meta Analysis
Meta-analysis of the effect of sodium-dependent glucose transporter 2 inhibitors on C-reactive protein in type 2 diabetes.
As novel hypoglycemic drugs, the effects of sodium-dependent glucose transporter 2 inhibitors (SGLT-2I) on inflammatory factors such as C-reactive protein (CRP) remain unclear. ⋯ International Prospective Register for Systematic Reviews (PROSPERO) number CRD42021268079.