Medicine
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Case Reports
Fatal abdominal hemorrhage following surgery to remove a retroperitoneal MPNST associated with NF1: A case report.
Individuals diagnosed with neurofibromatosis type I (NF1) commonly present with neurofibromas, and a subset may progress to develop malignant peripheral nerve sheath tumors (MPNST) during their lifetime. Diagnosing and treating MPNST, typically linked to NF1, poses challenges for clinicians due to its histopathological complexity. ⋯ It is crucial to assess the potential for heterogeneous differentiation in MPNST during pathological diagnosis. In the treatment of MPNST with heterogeneous differentiation, particularly in cases with significant tumor bulk, surgeons must anticipate potential hemorrhagic complications and adopt a cautious approach to surgical intervention.
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Observational Study
Impact of surgeon volume on the risk of complications following volar locking plating of unstable distal radius fracture.
Complications following volar locking plating (VLP) of distal radius fracture (DRF) are frequent. Increasing evidence has shown an inverse relationship between increased surgeon experience and fewer complications in a variety of surgeries, and this study aimed to verify whether this relationship existed when specified in the DRF surgically treated with VLP. Patients with an unstable DRF surgically treated by VLP in our institution between January 2016 and December 2021 were included. ⋯ Low-volume was associated with an increase in the risk of general complications by 4.8 times (95% confidential interval, 2.9-8.2). Subgroup analyses showed that this trend was intensified for AO type C fracture (odds ratio, 5.9), slightly mitigated for type B (odds ratio, 3.7), but not significant for type A. The finding highlighted the need to maintain 8 cases/year to improve the complications of DRFs, and for severe cases, centralized treatment is recommended.
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Comparative Study Observational Study
Comparison and analysis of alveolar bone structure characteristics in skeletal Class II and Class III malocclusion in the mandibular incisor region.
The aim of this study was to explore the differences in alveolar bone structure characteristics in skeletal class II and class III malocclusion in the mandibular incisor region. From January 2021 to November 2023, 100 cases of skeletal malocclusion patients were selected from our hospital, including 56 cases of skeletal Class II malocclusion and 44 cases of skeletal Class III malocclusion. The alveolar bone structure characteristics in the mandibular incisor region of skeletal class II and class III malocclusion patients are compared. ⋯ On the lingual side, the alveolar bone thickness below cementoenamel junction at 6 mm and at the root apex was (1.95 ± 0.45) mm2 and (1.92 ± 0.51) mm2, respectively, which were higher than in Class III malocclusion patients (P < .05). Compared to skeletal Class II malocclusion, in skeletal Class III malocclusion, the alveolar bone thickness in the mandibular incisor area is thinner and narrower. This should be given special attention during orthodontic treatment.
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Studies have shown that immune cells play an important role in the occurrence and development of pertussis, but the specific causal relationships are yet to be determined. Additionally, inflammatory cytokines, as regulators of immune responses, may mediate the relationship between immune cells and pertussis, and the specific mechanisms involved require further exploration. This study utilizes data from multiple large-scale genome-wide association studies, covering 731 types of immune cells and 91 types of inflammatory cytokines. ⋯ Additionally, 3 inflammatory cytokines - IL-4, IL-18R1, and FGF-21 - show a causal relationship with pertussis. Our mediation MR results indicate that inflammatory cytokines do not act as mediators in the relationship between immune cells and pertussis. This study suggests a causal relationship between immune cells and pertussis, while inflammatory cytokines do not appear to be mediating factors in the pathway from immune cells to pertussis.
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This study aimed to evaluate the effectiveness of the clinical nursing pathway model in the care of patients with mild acute pancreatitis (MAP). We conducted a retrospective analysis of medical records for 80 patients diagnosed with MAP at our hospital between September 2021 and March 2023. The patients were randomly assigned to 2 groups: the control group, which received routine nursing care, and the observation group, which followed the clinical nursing pathway. ⋯ Moreover, the observation group showed significantly higher scores for self-care ability and overall quality of life compared to the control group (P < .05). The clinical nursing pathway model significantly enhances the quality of care for patients with MAP by accelerating symptom relief, improving emotional status, reducing biochemical markers, and enhancing quality of life. This model effectively promotes both physical and mental health, increases self-care ability, and offers substantial potential for broader application in clinical practice.