Medicine
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Heavy metal water pollution refers to the abnormal concentration of metal elements and their compounds in water with a relative density of >4.5, which causes the water quality to decline or deteriorate. To assess the presence of 7 metals in drinking water in a city in Xinjiang and the health risks to the human body caused by drinking the water and to provide a scientific basis for health risk management for drinking water. In 2021, 114 monitoring points were set up in Urumqi, Xinjiang, China, and 228 water samples were collected in the dry and in the wet seasons to monitor water quality. ⋯ Based on noncarcinogenic health risk, the order of the 7 metals was Al > Fe > Gu > Mn > Hg > Zn > Pb, and the hazard index was 3.33 × 10-7 < 1. The total noncarcinogenic health risk of 7 metals was <1, that is, within the acceptable range. Al has the highest noncarcinogenic health risk, followed by Fe.
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The gut microbiota and inflammatory proteins may affect the development of peptic ulcer disease. However, this association remains unclear. We analyzed genome-wide association study data of gut microbiota, inflammatory proteins, and peptic ulcer disease using Mendelian randomization with instrumental variables to assess causal relationships. ⋯ Our findings reveal that the genus Butyriciccus plays a role in mitigating the adverse effects of gastric ulcers by 7.9%, primarily through reducing beta-negative growth factor levels. Additionally, the genus Lachnospiraceae UCG004 can significantly alleviate the negative outcomes of gastric ulcers and reduces hepatocyte growth factor and beta-reserve growth factor levels by 6.39% and 7.45%, respectively. This study highlights the independent and mediating effects of the gut microbiota and inflammatory proteins on peptic ulcers, offering insights on potential pathways and targets for future preventive interventions.
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Hemodialysis (HD)-related nursing research has been growing over the past 2 decades, providing critical insights into improving patient care and outcomes. This study aimed to visualize the hotspots and emerging frontiers in HD-related nursing research, offering valuable references for future studies. ⋯ This study reveals productive authors, countries and institutions, research hotspots, and trends of HD-related nursing research over the past 2 decades, offering a comprehensive overview of this field worldwide.
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Soft tissue management is critical in bone augmentation surgery to prevent wound dehiscence. Several strategies for passive tissue primary closure have been explored. This article introduces a flap design known as the modified "Poncho" technique (MPT), integrated with customized titanium mesh-mediated bone regeneration, and investigates the healing quality during the initial stages of an incision. ⋯ The MPT shows promise as an innovative approach for promoting passive and predictable primary wound closure beneath a digitally customized titanium mesh for bone regeneration, demonstrating a high rate of successful healing and minimal complications during the early postoperative phase.
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Alzheimer disease (AD), as the main type of dementia, is primarily characterized by cognitive dysfunction across multiple domains. Current drugs for AD have not achieved the desired clinical efficacy due to potential risks, inapplicability, high costs, significant side effects, and poor patient compliance. ⋯ Furthermore, it provides an overview of recent advances in clinical research on this drug. These findings suggest that SGLT-2i is poised to emerge as a pivotal candidate for the treatment of AD, given its diverse functional effects.