Medicine
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Acute infectious lymphangitis represents a common complication of cellulitis, typically attributed to streptococcal infections after damaged skin integrity. ⋯ A red stripe along the lymphatic route indicates acute lymphangitis and requires hospitalization for parenteral antibiotics.
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Currently, the number of patients with spinal stenosis is increasing, and most of the patients are found to have a history of smoking in the clinic. In this study, we used the Mendelian randomization (MR) method to investigate the causal relationship between smoking and spinal stenosis. ⋯ In this study, genetic data were analyzed and explored using 2-sample MR analysis, and the results showed that there is a causal relationship between smoking and the occurrence of spinal stenosis, and more studies need to be included.
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Meta Analysis
Association of circulating visfatin level and metabolic fatty liver disease: An updated meta-analysis and systematic review.
The rate of incidence of metabolic dysfunction-related fatty liver disease (MAFLD) has rapidly increased globally in recent years, but early diagnosis is still a challenge. The purpose of this systematic review and meta-analysis is to identify visfatin for early diagnosis of MAFLD. ⋯ The serum visfatin levels of MAFLD patients did not differ significantly from those of controls. However, visfatin concentrations in serum were statistically higher within Middle Eastern or obese MAFLD patients compared to controls. There is a need for further research to investigate visfatin's potential as a biomarker for MAFLD.
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Observational studies have established that obesity is associated with nutritional deficiencies, but the exact causality remains uncertain. Thus, this Mendelian randomization (MR) study aimed to identify the causal associations between obesity and circulating levels of nutrients. Single-nucleotide polymorphisms associated with obesity (body mass index and waist-hip ratio), were extracted from a genome-wide association study of 694,649 European ancestry. ⋯ Genetically predicted higher body mass index significantly decreased circulating levels of magnesium (β = -0.07, 95% confidence interval [CI]: -0.10 to -0.03, P = 1.47 × 10-4), folate (β = -0.07, 95% CI: -0.10 to -0.04, P = 5.61 × 10-5), vitamin A (β = -0.11, 95% CI: -0.14 to -0.07, P = 3.10 × 10-9), vitamin E (β = -0.10, 95% CI: -0.13 to -0.06, P = 1.84 × 10-8), albumin (β = -0.15, 95% CI: -0.17 to -0.12, P = 9.89 × 10-28); whereas genetically predicted higher waist-hip ratio decreased circulating levels of magnesium (β = -0.07, 95% CI: -0.11 to -0.02, P = 1.87 × 10-3), folate (β = -0.07, 95% CI: -0.11 to -0.03, P = 9.87 × 10-4), vitamin C (β = -0.08, 95% CI: -0.12 to -0.04, P = 2.40 × 10-4), albumin (β = -0.08, 95% CI: -0.11 to -0.04, P = 3.72 × 10-5). The study supports a causal effect of obesity on lower circulating levels of nutrients. Our findings highlight the necessity of adjuvant nutrients in obesity management.
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Case Reports
Rapid identification and management of stress-induced cardiomyopathy using POCUS after strangulation: A case report.
Stress-induced cardiomyopathy (SCMP), also known as Takotsubo syndrome, is a transient cardiac condition often precipitated by severe emotional or physical stress. It is commonly mistaken for acute coronary syndrome due to similar clinical presentations. The use of point-of-care ultrasound (POCUS) provides a noninvasive, rapid diagnostic alternative that can potentially reduce the need for invasive coronary angiography, especially in emergency settings. ⋯ This case underscores the diagnostic value of POCUS in rapidly identifying SCMP in emergency settings, which can guide timely and appropriate management. The noninvasive nature of POCUS may reduce the need for invasive diagnostics, minimize hospital stay duration, and enhance cost-effectiveness in managing SCMP.