Medicine
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Observational Study
Identification of DNA damage repair-related genes in sepsis using bioinformatics and machine learning: An observational study.
Sepsis is a life-threatening disease with a high mortality rate, for which the pathogenetic mechanism still unclear. DNA damage repair (DDR) is essential for maintaining genome integrity. This study aimed to explore the role of DDR-related genes in the development of sepsis and further investigated their molecular subtypes to enrich potential diagnostic biomarkers. ⋯ A notable difference in the immune microenvironment landscape was discovered between sepsis patients and healthy controls. Furthermore, all 3 genes were significantly associated with various immune cells. Our findings identify potential new diagnostic markers for sepsis that shed light on novel pathogenetic mechanism of sepsis and, therefore, may offer opportunities for potential intervention and treatment strategies.
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The present study aims to evaluate the adverse events associated with Capmatinib using real-world data, providing a reference basis for its rational use in clinical practice. Relevant data from the Food and Drug Administration adverse event reporting system database was mined. ⋯ A total of 79 signals were identified, with 13 of them not mentioned in the drug's specifications. Taken together, our comprehensive analysis of the Food and Drug Administration adverse event reporting system database enhances the understanding of Capmatinib's safety profile, thereby contributing to informed decision-making in its clinical application and facilitating the timely management of associated adverse reactions.
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Meta Analysis
Efficacy and safety of rifaximin for the prophylaxis of hepatic encephalopathy: A meta-analysis.
The efficacy of rifaximin in the prevention of overt hepatic encephalopathy (HE) has not been established. The aim of this study was to access the efficacy and safety of rifaximin in the prophylaxis of HE. ⋯ Rifaximin is beneficial for primary and secondary prevention of HE, but it does not reduce mortality or increase the incidence of adverse events in patients with end-stage cirrhosis caused by virus or alcohol.
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Asthma seriously affects people's survival and quality of life, causing a huge economic burden on society. Modern clinical use of Qianjinweijing Decoction (QJWJ) for the treatment of asthma has achieved good results. However, there is still a lack of research on its efficacy and mechanism of action. Therefore, the purpose of this study is to evaluate the efficacy of QJWJ in the treatment of asthma by systematic review and meta-analysis, and to explore its potential mechanism by network pharmacology. ⋯ QJWJ is effective in the treatment of asthma, and the therapeutic mechanism may be related to its regulation of inflammation, immunity, and apoptosis.
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Randomized Controlled Trial
Efficacy of toothpaste containing OPTIMEALTH® OR in inhibiting dental plaque and gingivitis: A randomized controlled trial.
This randomized double-blind, placebo-controlled clinical trial evaluated the effects of 2% OPTIMEALTH® OR toothpaste in regulating dental plaque microbiota and alleviating gingivitis. ⋯ Brushing teeth with 2% OPTIMEALTH® OR-fortified toothpaste could effectively reduce dental plaque and regulate plaque microbiota.