Medicine
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Bushen-Huoxue-Mingmu-Formula (MMF) has achieved definite clinical efficacy. However, its mechanism is still unclear. ⋯ MMF altered the expression of apoptosis- and autophagy-related proteins and possibly inhibited the Pink1/Parkin signaling pathway, which led to reduced pressurization-induced mitochondrial autophagy in RGCs. This preventive effect of MMF on RGCs can be potentially useful to preserve the viability of RGCs.
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Randomized Controlled Trial
The clinical effects of continuous nursing intervention combined with chronic disease management center in patients with severe hypertension.
The construction and application of chronic disease management centers are increasing. However, the effect of continuing nursing combined with intervention measures provided by chronic disease management centers in patients with severe hypertension is still unclear. To analyze the application effect of continuous nursing intervention combined with chronic disease management center in patients with severe hypertension. 240 patients with severe hypertension were randomly divided into control group (N = 120) and study group (N = 120). ⋯ After nursing, the short form 36-item health survey, total satisfaction rate and medication compliance rate of the study group were higher than those of the control group (P < .001). Blood pressure, self-rating anxiety scale, and self-rating depression scale scores were lower than those of the control group (P < .05). Continuing nursing combined with the intervention of chronic disease management center can effectively reduce the blood pressure of patients with severe hypertension, and the overall nursing effect is remarkable.
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This retrospective study aims to assess the adjunctive efficacy of warm needle moxibustion and gua sha care in the treatment of eszopiclone tablets on sleep quality and psychological stress in insomnia patients. Data of 138 insomnia patients from Gansu Baoshihua hospital between January and December 2022 were collected. Patients were bifurcated into 2 groups: those solely treated with eszopiclone (n = 71) and those administered a combined regimen of eszopiclone, warm needle moxibustion, and gua sha (n = 67). ⋯ The PSS-10 scores remained unchanged in both groups post-intervention. The intervention group reported a significant decrease in the prevalence of nausea and dizziness posttreatment (P < .05), with a notably lower post-intervention nausea prevalence compared to the control group (P < .05). Incorporating warm needle moxibustion and gua sha nursing care into the eszopiclone treatment regimen potentially amplify sleep quality while reducing side effects in patients with insomnia.
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Comparative Study
Internal fixation vs manual reduction in the treatment of ankle fracture healing and inflammation: A case-control study.
Ankle fractures are among the most common bone injuries, which are often accompanied by soft tissue injuries. Proper management of these fractures is crucial to promote healing and minimize complications. This study explores the effects of 2 treatment methods for ankle fractures: open reduction and internal fixation and manual reduction followed by plaster external fixation. ⋯ It leads to better fracture healing, shorter recovery times, and fewer complications, including nonunion. Manual reduction with external fixation remains a viable option but may be associated with a higher risk of nonunion and delayed healing. Early and effective management of soft tissue injuries is crucial for improving treatment outcomes in ankle fractures.
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Gitelman syndrome (GS) is a rare hereditary electrolyte disorder caused by mutations in the SLC12A3 gene. There is limited literature on the role of hydrochlorothiazide (HCT) testing and the SLC12A3 single heterozygous mutation in the diagnosis and management of patients with GS. In addition, cases of GS with concomitant kidney stones are rare. ⋯ When unexplained hypokalemia is observed, the HCT test can help with the diagnosis of GS. When genetic testing reveals that a patient only carries only 1 SLC12A3 mutant allele, he requires further genetic evaluation. The patient's combination of kidney stones and cysts could not exclude the diagnosis of GS. Patients with GS and diabetes should be monitored for the development of diabetic ketoacidosis.