JAMA : the journal of the American Medical Association
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Meta Analysis
The J-curve phenomenon and the treatment of hypertension. Is there a point beyond which pressure reduction is dangerous?
We critically appraised the medical literature to evaluate whether there is a point beyond which blood pressure reduction in hypertensive subjects is no longer beneficial and possibly even deleterious. Thirteen studies that stratified cardiovascular outcomes by level of achieved blood pressure in treated hypertensive subjects who had been followed up for at least 1 year were critiqued by four independent reviewers. ⋯ The beneficial therapeutic threshold point was 85 mm Hg. We conclude that low treated diastolic blood pressure levels, ie, below 85 mm Hg, are associated with increased risk of cardiac events.
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Biography Historical Article
The other Super Bowl question--can the NFL police its drug policy?