JAMA : the journal of the American Medical Association
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Multicenter Study
Results of radical prostatectomy in men with clinically localized prostate cancer.
To assess the results of radical prostatectomy in men with early prostate cancer. ⋯ Radical prostatectomy leads to high 10-year disease-specific survival rates in men with all tumor grades. However, caution is needed in comparing these results with similar studies of alternative treatment strategies, such as watchful waiting, due to the inherent potential biases in uncontrolled trials. Nevertheless, these results offer the best currently available estimates of 10-year outcome of radical prostatectomy in men with clinically localized prostate cancer and may be useful in counseling patients with early malignancy.
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To compare characteristics of homeless and low-income housed mothers across economic, psychosocial, and physical health domains. ⋯ Sheltered homeless mothers had fewer economic resources and social supports and higher cumulative rates of violent abuse and assault over their lifespans than their housed counterparts. However, both groups faced extreme adversity that compromised family well-being. Practitioners and social policymakers need to be cognizant of the multiple economic, psychosocial, and physical health needs of these mothers in providing treatment and developing program interventions.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Effects of pegorgotein on neurologic outcome of patients with severe head injury. A multicenter, randomized controlled trial.
To evaluate outcome of patients with severe closed head injury treated with pegorgotein, a scavenger of oxygen-derived free radicals. ⋯ In this clinical trial of 463 patients with severe head injury, no statistically significant difference in neurologic outcome or mortality was observed between patients treated with pegorgotein and those receiving placebo.