JAMA : the journal of the American Medical Association
-
To determine the relationship of brain infarction to the clinical expression of Alzheimer disease (AD). ⋯ These findings suggest that cerebrovascular disease may play an important role in determining the presence and severity of the clinical symptoms of AD.
-
Case Reports
Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation.
To characterize clinical features of a very large pedigree with early-onset Alzheimer disease (AD) in which all affected individuals carry the identical glutamic acid-to-alanine mutation at codon 280 in the presenilin-1 gene. ⋯ Other than the early onset, this clinical phenotype is indistinguishable from sporadic AD except that affected individuals frequently complained of headache preceding and during the disease. Despite the uniform genetic basis for the disease, there was significant variability in the age at onset, suggesting an important role for environmental factors or genetic modifiers in determining the age at onset.
-
To determine the frequency of unrecognized dementia in a group of men found to have dementia by population survey, and to identify factors associated with the failure of a family informant to recognize significant memory impairment. ⋯ Unrecognized dementia was common in our population, especially among mild cases. Cognitive screening programs for the elderly and public education policies designed to increase awareness of early signs of dementia are needed if interventions for individuals with potentially treatable dementias are to be implemented.