JAMA : the journal of the American Medical Association
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Randomized Controlled Trial
Effect of mass distribution of azithromycin for trachoma control on overall mortality in Ethiopian children: a randomized trial.
Mass oral azithromycin distribution to affected communities is a cornerstone of the World Health Organization's trachoma elimination program. Antibiotics are provided to target the ocular strains of chlamydia that cause trachoma, but may also be efficacious against respiratory disease, diarrhea, and malaria--frequent causes of childhood mortality in trachoma-endemic areas. ⋯ In a trachoma-endemic area, mass distribution of oral azithromycin was associated with reduced mortality in children.
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Comparative Study
Comparison of registered and published primary outcomes in randomized controlled trials.
As of 2005, the International Committee of Medical Journal Editors required investigators to register their trials prior to participant enrollment as a precondition for publishing the trial's findings in member journals. ⋯ Comparison of the primary outcomes of RCTs registered with their subsequent publication indicated that selective outcome reporting is prevalent.
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Randomized Controlled Trial Multicenter Study Comparative Study
Immediate vs delayed intervention for acute coronary syndromes: a randomized clinical trial.
International guidelines recommend an early invasive strategy for patients with high-risk acute coronary syndromes without ST-segment elevation, but the optimal timing of intervention is uncertain. ⋯ In patients with acute coronary syndromes without ST-segment elevation, a strategy of immediate intervention compared with a strategy of intervention deferred to the next working day (mean, 21 hours) did not result in a difference in myocardial infarction as defined by peak troponin level.