JAMA : the journal of the American Medical Association
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Randomized Controlled Trial Multicenter Study
Intraoperative high-dose dexamethasone for cardiac surgery: a randomized controlled trial.
Prophylactic corticosteroids are often administered during cardiac surgery to attenuate the inflammatory response to cardiopulmonary bypass and surgical trauma; however, evidence that routine corticosteroid use can prevent major adverse events is lacking. ⋯ In our trial of adults undergoing cardiac surgery, the use of intraoperative dexamethasone did not reduce the 30-day incidence of major adverse events compared with placebo.