JAMA : the journal of the American Medical Association
-
Randomized Controlled Trial Multicenter Study
Lansoprazole for children with poorly controlled asthma: a randomized controlled trial.
Asymptomatic gastroesophageal reflux (GER) is prevalent in children with asthma. Untreated GER has been postulated to be a cause of inadequate asthma control in children despite inhaled corticosteroid treatment, but it is not known whether treatment with proton pump inhibitors improves asthma control. ⋯ In this trial of children with poorly controlled asthma without symptoms of GER who were using inhaled corticosteroids, the addition of lansoprazole, compared with placebo, improved neither symptoms nor lung function but was associated with increased adverse events.
-
Randomized Controlled Trial Multicenter Study
Survival without disability to age 5 years after neonatal caffeine therapy for apnea of prematurity.
Very preterm infants are prone to apnea and have an increased risk of death or disability. Caffeine therapy for apnea of prematurity reduces the rates of cerebral palsy and cognitive delay at 18 months of age. ⋯ Neonatal caffeine therapy was no longer associated with a significantly improved rate of survival without disability in children with very low birth weights who were assessed at 5 years.