JAMA : the journal of the American Medical Association
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Randomized Controlled Trial
Chronic care management for dependence on alcohol and other drugs: the AHEAD randomized trial.
People with substance dependence have health consequences, high health care utilization, and frequent comorbidity but often receive poor-quality care. Chronic care management (CCM) has been proposed as an approach to improve care and outcomes. ⋯ Among persons with alcohol and other drug dependence, CCM compared with a primary care appointment but no CCM did not increase self-reported abstinence over 12 months. Whether more intensive or longer-duration CCM is effective requires further investigation.
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Are antioxidant supplements associated with higher or lower all-cause mortality? ⋯ Antioxidant supplements are not associated with lower all-cause mortality. Beta carotene, vitamin E, and higher doses of vitamin A may be associated with higher all-cause mortality.