JAMA : the journal of the American Medical Association
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The effect of prior SARS-CoV-2 infection on vaccine protection remains poorly understood. ⋯ Prior SARS-CoV-2 infection was associated with a statistically significantly lower risk for breakthrough infection among individuals receiving the BNT162b2 or mRNA-1273 vaccines in Qatar between December 21, 2020, and September 19, 2021. The observational study design precludes direct comparisons of infection risk between the 2 vaccines.