JAMA : the journal of the American Medical Association
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Depression, suicidal ideation, and self-harm behaviors in youth are associated with functional impairment and suicide. ⋯ Indirect evidence suggested that some screening instruments were reasonably accurate for detecting depression. Psychotherapy and pharmacotherapy were associated with some benefits and no statistically significant harms for depression, but the evidence was limited for suicide risk screening instruments and interventions.
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Data on the epidemiology of mild to moderately severe COVID-19 are needed to inform public health guidance. ⋯ In a cohort of US essential and frontline workers with SARS-CoV-2 infections, recent vaccination with 2 or 3 mRNA vaccine doses less than 150 days before infection with Delta or Omicron variants, compared with being unvaccinated, was associated with attenuated symptoms, duration of illness, medical care seeking, or viral load for some comparisons, although the precision and statistical significance of specific estimates varied.