JAMA : the journal of the American Medical Association
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Randomized Controlled Trial Multicenter Study
Prophylactic Oral Dextrose Gel and Neurosensory Impairment at 2-Year Follow-up of Participants in the hPOD Randomized Trial.
Prophylactic oral dextrose gel reduces neonatal hypoglycemia, but later benefits or harms remain unclear. ⋯ Among late preterm and term infants born at risk of neonatal hypoglycemia, prophylactic oral 40% dextrose gel at 1 hour of age, compared with placebo, resulted in no significant difference in the risk of neurosensory impairment at 2 years' corrected age. However, the study may have been underpowered to detect a small but potentially clinically important increase in risk, and further research including longer-term follow-up is required.
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Neonatal hypoglycemia is associated with increased risk of poor executive and visual-motor function, but implications for later learning are uncertain. ⋯ Among participants at risk of neonatal hypoglycemia who were screened and treated if needed, exposure to neonatal hypoglycemia compared with no such exposure was not significantly associated with lower educational achievement in mid-childhood.
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This study assesses trends in the percentage of adolescents with an unsuccessful cigarette quit attempt and compares quit attempts of combustible cigarettes and e-cigarettes in 2020.