JAMA : the journal of the American Medical Association
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Comment
Bempedoic Acid for Primary Prevention of Cardiovascular Events in Statin-Intolerant Patients.
The effects of bempedoic acid on cardiovascular outcomes in statin-intolerant patients without a prior cardiovascular event (primary prevention) have not been fully described. ⋯ In a subgroup of high-risk primary prevention patients, bempedoic acid treatment was associated with reduced major cardiovascular events.
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Randomized Controlled Trial Multicenter Study Comparative Study
Cytisinicline for Smoking Cessation: A Randomized Clinical Trial.
Cytisinicline (cytisine) is a plant-based alkaloid that, like varenicline, binds selectively to α4β2 nicotinic acetylcholine receptors, which mediate nicotine dependence. Although not licensed in the US, cytisinicline is used in some European countries to aid smoking cessation, but its traditional dosing regimen and treatment duration may not be optimal. ⋯ Both 6- and 12-week cytisinicline schedules, with behavioral support, demonstrated smoking cessation efficacy and excellent tolerability, offering new nicotine dependence treatment options.