JAMA : the journal of the American Medical Association
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Randomized Controlled Trial Comparative Study
Evaluation of Large-Scale Proteomics for Prediction of Cardiovascular Events.
Whether protein risk scores derived from a single plasma sample could be useful for risk assessment for atherosclerotic cardiovascular disease (ASCVD), in conjunction with clinical risk factors and polygenic risk scores, is uncertain. ⋯ A protein risk score was significantly associated with ASCVD events in primary and secondary event populations. When added to clinical risk factors, the protein risk score and polygenic risk score both provided statistically significant but modest improvement in discrimination.